منابع مشابه
RETRACTED: Cytohesins Are Cytoplasmic ErbB Receptor Activators
Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors. Cytohesin inhibition decreased ErbB receptor autophosphorylation and signaling, whereas cytohesin overex...
متن کاملCytohesins Are Cytoplasmic ErbB Receptor Activators
Anke Bill,1,8 Anton Schmitz,1,8 Barbara Albertoni,1 Jin-Na Song,1 Lukas C. Heukamp,2 David Walrafen,3 Franziska Thorwirth,4 Peter J. Verveer,4 Sebastian Zimmer,2 Lisa Meffert,2 Arne Schreiber,3 Sampurna Chatterjee,5 Roman K. Thomas,5,6,7 Roland T. Ullrich,5 Thorsten Lang,3 and Michael Famulok1,* 1LIMES Institute, Program Unit Chemical Biology & Medicinal Chemistry, Laboratory of Chemical Biolog...
متن کاملOligosaccharides of hyaluronan are potent activators of dendritic cells.
The extracellular matrix component hyaluronan (HA) exists physiologically as a high m.w. polymer but is cleaved at sites of inflammation, where it will be contacted by dendritic cells (DC). To determine the effects of HA on DC, HA fragments of different size were established. Only small HA fragments of tetra- and hexasaccharide size (sHA), but not of intermediate size (m.w. 80, 000-200,000) or ...
متن کاملCytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor
Cytochrome P450 (P450) eicosanoids regulate vascular tone, renal tubular transport, cellular proliferation, and inflammation. Both the CYP4A -hydroxylases, which catalyze 20-hydroxyeicosatetraenoic acid (20-HETE) formation, and soluble epoxide hydrolase (sEH), which catalyzes epoxyeicosatrienoic acid (EET) degradation to the dihydroxyeicosatrienoic acids (DHETs), are induced upon activation of ...
متن کاملSome taste substances are direct activators of G-proteins.
Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that am...
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ژورنال
عنوان ژورنال: ChemPhysChem
سال: 2021
ISSN: 1439-4235,1439-7641
DOI: 10.1002/cphc.202100268